FGF‐2 promotes initial osseointegration and enhances stability of implants with low primary stability
Identifieur interne : 000826 ( Main/Exploration ); précédent : 000825; suivant : 000827FGF‐2 promotes initial osseointegration and enhances stability of implants with low primary stability
Auteurs : Toshie Nagayasu-Tanaka ; Takenori Nozaki ; Koji Miki ; Keigo Sawada ; Masahiro Kitamura ; Shinya MurakamiSource :
- Clinical Oral Implants Research [ 0905-7161 ] ; 2016.
Abstract
The aim of this study was to examine the effect of basic fibroblast growth factor (
Customized titanium implants that were designed to have low contact with the existing bone were installed into the edentulous mandible of beagle dogs. To degrade the primary stability of the implants, the diameters of the bone sockets exceeded the implant diameters.
The histomorphometric analysis revealed that the new bone area and length of
Taken together, our study demonstrates that
Url:
DOI: 10.1111/clr.12797
PubMed: 26919334
PubMed Central: 5347960
Affiliations:
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Le document en format XML
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<author><name sortKey="Nagayasu Anaka, Toshie" sort="Nagayasu Anaka, Toshie" uniqKey="Nagayasu Anaka T" first="Toshie" last="Nagayasu-Tanaka">Toshie Nagayasu-Tanaka</name>
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<author><name sortKey="Miki, Koji" sort="Miki, Koji" uniqKey="Miki K" first="Koji" last="Miki">Koji Miki</name>
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<author><name sortKey="Sawada, Keigo" sort="Sawada, Keigo" uniqKey="Sawada K" first="Keigo" last="Sawada">Keigo Sawada</name>
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<author><name sortKey="Kitamura, Masahiro" sort="Kitamura, Masahiro" uniqKey="Kitamura M" first="Masahiro" last="Kitamura">Masahiro Kitamura</name>
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<author><name sortKey="Murakami, Shinya" sort="Murakami, Shinya" uniqKey="Murakami S" first="Shinya" last="Murakami">Shinya Murakami</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">FGF‐2 promotes initial osseointegration and enhances stability of implants with low primary stability</title>
<author><name sortKey="Nagayasu Anaka, Toshie" sort="Nagayasu Anaka, Toshie" uniqKey="Nagayasu Anaka T" first="Toshie" last="Nagayasu-Tanaka">Toshie Nagayasu-Tanaka</name>
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<author><name sortKey="Nozaki, Takenori" sort="Nozaki, Takenori" uniqKey="Nozaki T" first="Takenori" last="Nozaki">Takenori Nozaki</name>
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<author><name sortKey="Miki, Koji" sort="Miki, Koji" uniqKey="Miki K" first="Koji" last="Miki">Koji Miki</name>
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</affiliation>
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<author><name sortKey="Sawada, Keigo" sort="Sawada, Keigo" uniqKey="Sawada K" first="Keigo" last="Sawada">Keigo Sawada</name>
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<author><name sortKey="Kitamura, Masahiro" sort="Kitamura, Masahiro" uniqKey="Kitamura M" first="Masahiro" last="Kitamura">Masahiro Kitamura</name>
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<author><name sortKey="Murakami, Shinya" sort="Murakami, Shinya" uniqKey="Murakami S" first="Shinya" last="Murakami">Shinya Murakami</name>
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<series><title level="j">Clinical Oral Implants Research</title>
<idno type="ISSN">0905-7161</idno>
<idno type="eISSN">1600-0501</idno>
<imprint><date when="2016">2016</date>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<sec id="clr12797-sec-0001"><title>Objectives</title>
<p>The aim of this study was to examine the effect of basic fibroblast growth factor (<styled-content style="fixed-case">FGF</styled-content>
‐2) on osseointegration of dental implants with low primary stability in a beagle dog model.</p>
</sec>
<sec id="clr12797-sec-0002"><title>Materials and methods</title>
<p>Customized titanium implants that were designed to have low contact with the existing bone were installed into the edentulous mandible of beagle dogs. To degrade the primary stability of the implants, the diameters of the bone sockets exceeded the implant diameters. <styled-content style="fixed-case">FGF</styled-content>
‐2 (0.3%) plus vehicle (hydroxypropyl cellulose) or vehicle alone was topically applied to the sockets in the <styled-content style="fixed-case">FGF</styled-content>
‐2 and control groups, respectively. In Study 1, the new bone area and length of new bone‐to‐implant contact (<styled-content style="fixed-case">BIC</styled-content>
) were evaluated at 4, 8, and 12 weeks after installation using histomorphometry and scanning electron microscopy. In Study 2, the implant stability quotient (<styled-content style="fixed-case">ISQ</styled-content>
) values were sequentially measured for 16 weeks using an Osstell system.</p>
</sec>
<sec id="clr12797-sec-0003"><title>Results</title>
<p>The histomorphometric analysis revealed that the new bone area and length of <styled-content style="fixed-case">BIC</styled-content>
in the <styled-content style="fixed-case">FGF</styled-content>
‐2 group were significantly larger than those in the control group at 4 weeks. Electron microscopic observation showed intimate contact between the mature lamellar bone and the implant surfaces, osseointegration, in both groups. The <styled-content style="fixed-case">ISQ</styled-content>
values in the <styled-content style="fixed-case">FGF</styled-content>
‐2 group were significantly increased from 6 to 16 weeks compared with those in the control group.</p>
</sec>
<sec id="clr12797-sec-0004"><title>Conclusions</title>
<p>Taken together, our study demonstrates that <styled-content style="fixed-case">FGF</styled-content>
‐2 promoted new bone formation around the dental implants and subsequent osseointegration, resulting in promotion of stability of implants with low primary stability.</p>
</sec>
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<tree><noCountry><name sortKey="Kitamura, Masahiro" sort="Kitamura, Masahiro" uniqKey="Kitamura M" first="Masahiro" last="Kitamura">Masahiro Kitamura</name>
<name sortKey="Miki, Koji" sort="Miki, Koji" uniqKey="Miki K" first="Koji" last="Miki">Koji Miki</name>
<name sortKey="Murakami, Shinya" sort="Murakami, Shinya" uniqKey="Murakami S" first="Shinya" last="Murakami">Shinya Murakami</name>
<name sortKey="Nagayasu Anaka, Toshie" sort="Nagayasu Anaka, Toshie" uniqKey="Nagayasu Anaka T" first="Toshie" last="Nagayasu-Tanaka">Toshie Nagayasu-Tanaka</name>
<name sortKey="Nozaki, Takenori" sort="Nozaki, Takenori" uniqKey="Nozaki T" first="Takenori" last="Nozaki">Takenori Nozaki</name>
<name sortKey="Sawada, Keigo" sort="Sawada, Keigo" uniqKey="Sawada K" first="Keigo" last="Sawada">Keigo Sawada</name>
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